Ivermectin Mebendazole Tablet

Ivermectin-Mebendazole – Combination Antiparasitic

Ivermectin-Mebendazole contains Ivermectin + Mebendazole, a combination antiparasitic indicated for mixed intestinal worm infections with ectoparasite co-infestation; combined deworming. WHO MDA combinations use ivermectin + albendazole; ivermectin-mebendazole used in clinical practice for mixed infections.

Product Information

People Also Ask

Why combine ivermectin and mebendazole?

Ivermectin targets filarial microfilariae, Strongyloides, and ectoparasites (scabies, lice). Mebendazole targets intestinal nematodes (roundworm, hookworm, whipworm, pinworm). In tropical regions, patients commonly harbour both types simultaneously — a combination treats both infections in one course, improving compliance and efficiency versus sequential treatments.

Can ivermectin and mebendazole be taken together?

Yes — the two drugs have no clinically significant pharmacokinetic interactions. They work at completely different sites: ivermectin systemically affects neuromuscular transmission in susceptible parasites while mebendazole works locally in the intestinal lumen by inhibiting tubulin polymerisation. Clinical combination use is established practice.

Is ivermectin-mebendazole better than albendazole alone?

For mixed infections including Strongyloides or ectoparasites, yes — albendazole alone misses these targets. For standard intestinal deworming (roundworm, hookworm, pinworm), albendazole or mebendazole alone are equivalent and simpler. The ivermectin combination adds value specifically when ivermectin-sensitive parasites are part of the clinical picture.

What are the side effects of ivermectin-mebendazole?

Mebendazole is minimally absorbed and rarely causes systemic side effects; mild GI upset is possible. Ivermectin may cause headache, dizziness, nausea, and die-off reactions (fever, rash) from parasite lysis. Ivermectin should be taken on an empty stomach; mebendazole with food for best effect.

How many doses of ivermectin-mebendazole are needed?

For most mixed infections, a single dose of each component suffices. Ivermectin is typically given as a single dose (200mcg/kg). Mebendazole may be 100mg twice daily for 3 days (for roundworm/hookworm/whipworm) or 500mg single dose (for broader spectrum). A repeat dose may be advised at 2 weeks for scabies.

How it works

Ivermectin: glutamate-gated chloride channel disruptor causing nematode/ectoparasite paralysis. Mebendazole: tubulin polymerisation inhibitor blocking glucose absorption in intestinal worms — making Ivermectin + Mebendazole effective against mixed intestinal worm infections with ectoparasite co-infestation; combined deworming.

The ivermectin-mebendazole combination treats mixed parasitic infections where both ectoparasites/filarial worms (ivermectin's target) and intestinal nematodes (mebendazole's target) are present simultaneously. It provides broader antiparasitic coverage than either drug alone in a single treatment course. This combination is used in tropical regions with high co-infection rates.

Storage

Store at 15–30°C away from sunlight and moisture. Keep out of reach of children.