Spironolactone 100mg Tablet

Spironolactone 100mg Tablet is a prescription potassium-sparing diuretic, aldosterone antagonist and antiandrogen used in the management of conditions including edema, heart failure, hypertension and hyperaldosteronism. Because spironolactone also has antiandrogenic activity, it is prescribed in selected patients for hormonal acne and may be used as an antiandrogen in feminizing hormone therapy (HRT) under appropriate medical supervision.

Aldactone® is a reference brand containing spironolactone. An appropriately authorized generic Spironolactone 100mg Tablet contains the same active pharmaceutical ingredient, although manufacturer, formulation, packaging and regulatory status can vary between markets.

Product Information

Generic Name

Spironolactone

Strength

100mg

Dosage Form

Tablet

Drug Class

Potassium-Sparing Diuretic; Aldosterone Antagonist; Antiandrogen

Reference Brand

Aldactone®

Active Ingredient

Spironolactone

Route

Oral

Primary Uses

Edema, heart failure, hypertension, hyperaldosteronism

Dermatological Use

Hormonal acne

HRT Use

Antiandrogen in selected feminizing hormone therapy regimens

Prescription

Yes

Pack Size

Manufacturer and market dependent

Monitoring

Serum potassium and kidney function may require monitoring

What Is Spironolactone 100mg Tablet?

Spironolactone is a mineralocorticoid receptor antagonist with potassium-sparing diuretic and antiandrogenic properties.

It blocks the action of aldosterone, a hormone that promotes sodium and water retention. By reducing aldosterone activity, spironolactone increases the elimination of sodium and water while reducing potassium loss.

Spironolactone also has antiandrogenic effects. This makes it clinically useful in selected patients with hormonal acne and as an antiandrogen in some feminizing HRT protocols.

Spironolactone 100mg for Acne

Spironolactone is commonly prescribed for hormonal acne, particularly when androgen activity contributes to persistent or recurrent acne.

Its antiandrogenic effects may reduce androgen-driven sebum production and help control acne breakouts in appropriate patients.

Spironolactone is not an antibiotic. It addresses hormonal pathways that may contribute to acne and is generally considered when conventional acne treatments are inadequate or hormonal factors are clinically relevant.

Spironolactone 100mg for Hormonal Acne

Hormonal acne frequently affects the chin, jawline and lower face and may fluctuate with hormonal changes.

Spironolactone can reduce androgen activity and may therefore help reduce excess oil production and acne in selected patients.

A 100mg tablet represents a higher tablet strength than 25mg or 50mg formulations. The appropriate dose for acne varies by patient and should be established by a healthcare professional.

Spironolactone 100mg for HRT

Spironolactone 100mg may be prescribed as an antiandrogen in feminizing hormone therapy (HRT).

Its purpose in HRT is to reduce androgen activity. Spironolactone is not estrogen and does not replace estrogen therapy.

Depending on the treatment plan, it may be prescribed alongside estrogen under specialist supervision.

Medical monitoring may include:

• Serum potassium
• Kidney function
• Blood pressure
• Hormone levels when clinically indicated
• Overall treatment response

HRT protocols differ between countries and individual patients, so treatment should be medically individualized.

Spironolactone 100mg as an Antiandrogen

Spironolactone has antiandrogenic properties that can reduce the effects of testosterone and other androgen hormones.

It may be used in selected patients for:

• Hormonal acne
• Hirsutism
• Androgen-related dermatological conditions
• Feminizing HRT
• Other specialist-managed antiandrogen indications

The appropriate dose depends on the treatment objective and individual patient factors.

Spironolactone 100mg for Edema

Spironolactone may be prescribed to manage edema and fluid retention associated with selected cardiovascular, hepatic and renal conditions.

It promotes sodium and water excretion while conserving potassium.

The underlying cause of edema should be diagnosed before treatment, as appropriate therapy depends on the underlying condition.

Spironolactone 100mg for Heart Failure

Spironolactone is an established aldosterone antagonist used in appropriate patients with heart failure.

By blocking aldosterone, it can reduce sodium and fluid retention and provide additional cardiovascular benefits in selected patients.

Patients receiving spironolactone for heart failure require appropriate monitoring of kidney function and serum potassium.

Spironolactone 100mg for Hypertension

Spironolactone can lower blood pressure and may be prescribed for hypertension, particularly when excess aldosterone contributes to elevated blood pressure or when additional antihypertensive treatment is required.

Spironolactone 100mg for Hyperaldosteronism

Spironolactone is commonly used for primary hyperaldosteronism because it blocks the effects of excessive aldosterone.

The required total daily dose depends on the severity of aldosterone excess, treatment response and individual patient factors.

Spironolactone 100mg and Aldactone®

Aldactone® is a reference brand containing spironolactone.

An appropriately authorized generic Spironolactone 100mg product contains the same active pharmaceutical ingredient. Manufacturer, inactive ingredients, packaging and regulatory authorization can differ by market.

Common commercial searches include:

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Spironolactone 100mg Monitoring

Healthcare professionals may monitor:

• Serum potassium
• Kidney function
• Blood pressure
• Electrolytes where clinically appropriate
• Fluid status
• Treatment response

Monitoring is particularly important after treatment initiation or dose changes and in patients with kidney impairment or those taking other potassium-affecting medicines.

Spironolactone 100mg and Potassium

Spironolactone is a potassium-sparing medicine and can increase potassium levels.

The risk of hyperkalemia may be increased by:

• Kidney impairment
• ACE inhibitors
• ARBs
• Potassium supplements
• Potassium-containing salt substitutes
• Other potassium-sparing medicines

Do not take potassium supplements or potassium-containing salt substitutes unless specifically recommended by a healthcare professional.

Availability & Ordering

Spironolactone 100mg Tablet is a prescription medicine supplied through appropriately licensed pharmacies and pharmaceutical suppliers.

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Availability, prescription requirements, approved indications and import regulations vary across the USA, UK, UAE/Dubai, Australia, Singapore, Thailand, China and Russia.

How it works

Spironolactone works through two clinically important mechanisms.

Aldosterone Antagonist

Spironolactone blocks mineralocorticoid receptors activated by aldosterone. This promotes sodium and water excretion while conserving potassium.

Antiandrogenic Activity

Spironolactone also reduces androgen-mediated effects. This can decrease androgen stimulation of sebaceous glands and other androgen-sensitive tissues.

This antiandrogenic activity explains its use in hormonal acne and as an androgen blocker in selected feminizing HRT regimens.

Spironolactone 100mg may be prescribed for:

• Edema and fluid retention
• Heart failure
• Hypertension
• Primary hyperaldosteronism
• Secondary hyperaldosteronism
• Hormonal acne
• Certain androgen-related conditions
• Antiandrogen therapy in feminizing HRT

The approved uses of spironolactone differ between countries. Some dermatological and hormone-related uses may be off-label depending on the jurisdiction.

The appropriate spironolactone dose depends on the indication, clinical response, kidney function, serum potassium, blood pressure and other medicines.

A 100mg tablet may be used as part of an individualized treatment regimen for certain conditions. The dose required for acne, HRT, edema, hypertension or hyperaldosteronism can differ substantially.

Do not use the 100mg strength simply because it is a higher-strength tablet. Your healthcare professional should determine the appropriate dose and treatment schedule.

Do not increase, decrease or discontinue spironolactone without medical advice.

Possible side effects include:

• Increased urination
• Dizziness
• Headache
• Nausea
• Vomiting
• Stomach discomfort
• Fatigue
• Breast tenderness
• Menstrual irregularities
• Changes in libido
• Increased potassium levels

Because of its antiandrogenic effects, gynecomastia may occur in some men.

Hyperkalemia, or excessively high potassium, can be serious and is more likely in patients with kidney impairment or those taking other potassium-raising medicines.

Potentially important interactions include:

• ACE inhibitors
• Angiotensin II receptor blockers
• Potassium supplements
• Potassium-containing salt substitutes
• Other potassium-sparing diuretics
• Certain NSAIDs
• Medicines affecting kidney function
• Other medicines that increase serum potassium

Tell your healthcare professional about all prescription medicines, over-the-counter medicines, vitamins and supplements before starting treatment.