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Fluorouracil Cream 5%

Cream · 1 Cream per Box

$114.00 incl. taxes

Composition: —
Manufacturer: Menarini
Pack: 1 Cream per Box

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About Fluorouracil Cream 5%

Drug: Fluorouracil (5-FU) | Class: Topical Pyrimidine Antimetabolite / Chemotherapy | Brand: Efudex 5% (Valeant); Fluorac 5% (Sun Pharma India), Flonida 5% (Menarini) | Indication: Actinic keratosis, superficial basal cell carcinoma, Bowen's disease — pre-cancerous and early cancerous skin lesions | Dose: Actinic keratosis: apply twice daily × 2–4 weeks

Fluorouracil Cream 5%-10g – Topical Pyrimidine Antimetabolite / Chemotherapy

Fluorouracil Cream 5%-10g contains Fluorouracil (5-FU), a topical pyrimidine antimetabolite / chemotherapy for actinic keratosis, superficial basal cell carcinoma, bowen's disease — pre-cancerous and early cancerous skin lesions. FDA-approved; Cochrane: 5-FU cream 80% clearance for actinic keratosis; field therapy prevents field cancerisation; NICE-listed.

Product Information

Attribute	Details
Generic Name	Fluorouracil (5-FU)
Drug Class	Topical Pyrimidine Antimetabolite / Chemotherapy
Brand Reference	Efudex 5% (Valeant); Fluorac 5% (Sun Pharma India)
Indication	Actinic keratosis, superficial basal cell carcinoma, Bowen's disease — pre-cancerous and early cancerous skin lesions
Standard Dose	Actinic keratosis: apply twice daily × 2–4 weeks. Superficial BCC: apply twice daily × 3–6 weeks. Significant inflammatory reaction is expected — indicates treatment working
Form	Topical Cream
Route	Topical
Prescription	Yes
Evidence	FDA-approved; Cochrane: 5-FU cream 80% clearance for actinic keratosis; field therapy prevents field cancerisation; NICE-listed

Why does flurouracil cream cause such inflammation?

The redness, burning, crusting, and erosion during 5-FU treatment are caused by the drug selectively attacking rapidly dividing abnormal cells — exactly the intended action. Areas with more precancerous cells react more intensely. The reaction typically peaks at weeks 2–3 then resolves. This is not an allergic reaction but the therapeutic response. Treatment must be continued through the inflammatory phase.

How long does fluorouracil cream need to be used?

Actinic keratosis: 2–4 weeks twice daily. Superficial BCC: 4–6 weeks twice daily. Healing after stopping takes 2–4 additional weeks. A treated area may appear worse before it looks better — this is normal.

Can fluorouracil cream cause scarring?

Correctly used fluorouracil cream typically heals without scarring. However, if the inflammatory reaction is severe or becomes infected, some residual textural change is possible. Sun protection after treatment is essential — treated skin is more photosensitive.

What is field therapy for actinic keratosis?

Field therapy treats a large area of sun-damaged skin rather than individual lesions — addressing visible and subclinical precancerous cells ('field cancerisation'). Fluorouracil cream applied to the entire forehead/scalp/face treats all precancerous areas simultaneously, preventing future progression to squamous cell carcinoma.

Does fluorouracil cream treat melanoma?

No — 5-FU cream is only indicated for superficial non-melanoma skin cancers (actinic keratosis, superficial BCC) and Bowen's disease. It is not appropriate for melanoma, nodular BCC, or invasive squamous cell carcinoma — these require surgical or systemic treatment.

How it works

Inhibits thymidylate synthase blocking DNA synthesis; rapidly dividing cells (pre-cancerous keratinocytes) accumulate 5-FU at higher concentrations and undergo apoptosis.