Progesterone 100mg Capsules

Progesterone 100 mg Capsules ( Susten 100mg ) are manufactured utilizing state-of-the-art micronization protocols. By drastically reducing the active hormone crystal size, this process ensures smooth, uniform gastrointestinal absorption and optimal systemic bioavailability. As a bioidentical progestogen, it delivers target-tissue protection without the undesirable metabolic, fluid-retaining, or androgenic side effects associated with synthetic progestins.

• Continuous Endometrial Protection: For women with an intact uterus undergoing daily menopausal estrogen replacement, a continuous low-dose progestogen is vital. Micronized progesterone binds to uterine progesterone receptors, arresting estrogen-driven tissue proliferation and transforming the endometrium into a stable, healthy secretory state.

• Neurosteroid GABA-A Modulation: Following oral ingestion, the compound metabolizes partly into allopregnanolone, a neurosteroid that crosses the blood-brain barrier. It acts as a positive allosteric modulator of central $GABA_A$ receptors, which helps soothe the nervous system, alleviate evening anxiety, and promote stable sleep architecture.

• Continuous Combined Menopausal HRT: Administered daily alongside estrogen to maintain long-term, bleed-free uterine safety in postmenopausal women.

• Hormonal Cycle Regulation: Restores regular bleeding patterns in women experiencing dysfunctional uterine bleeding or secondary amenorrhea.

• Luteal Phase Support: Provides continuous, low-dose hormonal reinforcement to support early uterine lining preparation in fertility care.

• Perimenopausal Transitions: Smooths out the volatile hormonal fluctuations, mood disturbances, and sleep disruptions typical of early perimenopause.

Clinical Advantages & Key Benefits

• Bioidentical Safety Profile: Identical to native human progesterone, offering a highly natural physiological response with superior long-term tissue tolerance.

• Flexible Dual-Route Delivery: The specialized soft gelatin capsule structure allows for seamless oral ingestion or localized vaginal administration based on patient requirements.

• Cardiovascular and Metabolic Neutrality: Does not negatively alter beneficial HDL/LDL cholesterol profiles or counteract the cardioprotective benefits of concurrent estrogen therapy.

• Restful Sleep Promotion: Safely capitalizes on natural somnolytic pathways when taken at night, directly addressing menopausal insomnia.

• Continuous Menopausal HRT Regimen: The standard protocol generally requires one 100 mg capsule taken orally every single night without interruption, maintaining a thin, bleed-free endometrial lining.

• Administration Protocols:

  • Oral Use: Ingest on an empty stomach right before bedtime to maximize absorption and align its natural calming properties with your sleep cycle.

  • Vaginal Use: Insert the soft gel capsule deep into the vaginal canal as directed by your fertility or endocrine specialist.

• Storage Requirements: Store in a cool, stable environment below 25°C. Keep the original blister strips or container tightly sealed to protect the soft gelatin shells from moisture and high humidity.

• Common Oral Manifestations: Minor dizziness, transient evening drowsiness, mild abdominal bloating, temporary breast tenderness, or occasional fluid retention during the first few weeks of administration.

• Daytime Safety Warning: Due to the potential for temporary lightheadedness or motor relaxation following oral intake, avoid driving or operating complex machinery immediately after consuming the capsule.

• Strict Contraindications: Do not use if you have active or a history of deep vein thrombosis (DVT), pulmonary embolism, undiagnosed abnormal vaginal bleeding, severe liver dysfunction, or known or suspected progestogen-sensitive malignancies.